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Diagnosis and what to expect

See how doctors diagnose prostate cancer.

Prostate cancer often develops without symptoms early on. Some people first learn about prostate cancer through routine screening tests, like a prostate-specific antigen (PSA) test.

If results suggest cancer, a urologist may perform a prostate biopsy to confirm a diagnosis. Imaging tests can also be used to help show whether cancer is limited to the prostate or has spread beyond it.

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PSA test

A PSA test is a blood test that measures PSA levels in your body. Levels below about 4.0 ng/mL are often considered within a typical range, though this can vary based on age and other factors. Higher-than-expected results may lead to additional testing to learn more.

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Biopsy

During a biopsy, a urologist removes small samples of tissue from the prostate using a thin needle. The samples are examined in a laboratory under a microscope to check for cancer cells. Imaging tests such as ultrasound or MRI may be used during diagnosis to help guide next steps.

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Biomarker testing

Biomarkers are signals in cancer cells that can show how cancer may change, grow or respond to treatment. Biomarker testing may be done at the same time as a biopsy.

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Have you asked about biomarker testing?

Biomarker testing can help your care team design a treatment plan tailored to you. We’ll help you build a discussion guide you can take to your next visit.

Get started

Take a deeper look at biomarkers

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Not all prostate cancer types are the same.

Once diagnosed, doctors look at where the cancer started and certain features to determine the type. Knowing the specific type can help guide treatment decisions and next steps.

The most common type of prostate cancer is adenocarcinoma, but there are other less common types as well.

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Adenocarcinoma

Most prostate cancers are adenocarcinomas. They begin in the prostate’s gland cells, which make fluid that becomes part of semen.

Because this is the most common type of prostate cancer, much of what you may read about prostate cancer refers to adenocarcinoma.

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Other types of prostate cancer

  • Small cell carcinomas
  • Neuroendocrine tumors
  • Transitional cell carcinomas
  • Sarcomas

These less common prostate cancer types may behave differently than adenocarcinoma and may be treated differently.

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Explore treatment types

There’s more than one way to treat prostate cancer.

Your prostate cancer treatment plan depends on several factors, including:

  • The stage of your cancer
  • Your PSA level and Gleason score
  • Your overall health
  • Your age

Your preferences and goals for treatment

Knowing about your options can help you have informed conversations with your doctor and take an active role in your care.

Remember to ask about the side effects, risks, and benefits of any cancer treatment.

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Active surveillance

Active surveillance is a common first approach for some people with prostate cancer. Instead of starting treatment right away, doctors may recommend closely monitoring the cancer over time.

This approach is often used when the cancer is growing slowly and not causing harm. Monitoring helps doctors watch for changes and decide if treatment is needed later. It may also help people avoid treatment side effects unless they become necessary.

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Surgery

Surgery may be one option for treating prostate cancer that has not spread beyond the prostate.

One common type of surgery is called a prostatectomy, which removes the prostate gland and sometimes nearby lymph nodes to check whether cancer has spread.

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Radiation therapy

Radiation therapy uses high-energy rays to destroy cancer cells. It is often used after surgery to lower the risk of the cancer coming back. Different radiation techniques may be used depending on a person’s treatment plan.

In some cases, radiation may be delivered internally using small radioactive “seeds” placed inside the prostate. Over time, the radiation fades, and the seeds that remain in the prostate are harmless.

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Chemotherapy

Chemotherapy, or chemo, uses a combination of two or three powerful medications to attack and stop cancer cells from growing. It can also kill some healthy cells, which is why people may experience side effects, like hair loss. Typically a fluid delivered into a vein (IV), it may also be given as an injection or pills.

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Hormone therapy

Hormone therapy lowers the level of male hormones in the body or blocks their effects on prostate cancer cells.

Prostate cancer cells often rely on these hormones, called androgens, to grow. Hormone therapy can help slow the growth of the cancer or shrink tumors.

Hormone therapy may be used on its own or combined with other treatments, depending on the stage of the cancer and your treatment plan.

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Targeted therapy

Targeted therapy is designed to act on specific features of cancer cells, such as proteins or gene changes identified through biomarker testing, although it can also affect some normal cells. It’s also called personalized or individualized therapy.

Targeted therapy can be given as a pill, infusion (IV), or injection.

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Clinical trials

If available treatments aren’t a fit for your particular cancer, participating in a clinical trial may be right for your situation. Clinical trials study the safety and efficacy of potential new medicines, including cancer treatments. Your doctor can tell you about the benefits and risks, and whether taking part in a clinical trial is right for you.

Explore clinical trials

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Ways to work with your care team

From questions to clarity, your doctor can help.

Diagnosis, testing, and treatment types can bring lots of questions. We can help prepare you to get the most out of your conversations.

Get ready

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Unsure what to ask? Let’s get you started.
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Diagnosis
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Get answers about your diagnosis.

  • What type of cancer do I have?
  • Has it spread or grown?
  • What stage is my cancer?

Get more diagnosis questions

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Talk about your treatment plan.

  • What types of treatment are used for my cancer?
  • If biomarker testing was done, how do the results impact my treatment plan?
  • What are the goals of my treatment plan?

Get more treatment questions

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Ask about support and resources.

  • What support services are available?
  • Who can help me navigate care and next steps?
  • Who on my care team can I reach out to when I have questions?

Get more support questions

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We’re committed to helping you afford your Pfizer prescriptions.

From co-pay cards to help navigating insurance approvals, we’ll guide you to the right support. And if you’re eligible for our programs, we’ll help you get the Pfizer medicines you need.

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You could help advance a breakthrough.

Clinical trials study the safety and efficacy of potential new medicines, including cancer treatments.

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Explore clinical trials
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Living with cancer

Get a little inspiration.

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Fear and over-analysis can lead to doing nothing. Don’t let fear stop you from moving forward.”

Marc

Actual patient with cancer

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When I'm playing music, my mind is occupied with what I'm doing, so it can't be occupied with thinking about my cancer.”

Billy

Actual patient with cancer

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Still have questions?

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What are targeted therapies?

Targeted therapies are treatments that target the ways cancer cells grow, divide, and spread. One of the ways doctors determine if targeted therapies make sense in a treatment plan is through biomarker testing.

Find out more about biomarker testing

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What can I do if I’m having trouble affording my medicine?

Managing treatment costs and paying for your medicine can be overwhelming. We’ve got resources on how to help manage costs and information on where you may be able to find financial support for Pfizer medications.

Get help navigating costs

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Can I still go to work if I’m getting cancer treatment?

About half of people living with cancer are at an age where they’re still working. If you’re one of them, you may be wondering about how to talk to your co-workers about what you’re going through, what you need, and your ability to do your job. We’ve got you covered.

Communicating what you need at work

Getting back to work after treatment

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Are there communities and advocacy groups I can join?

There are advocacy support resources available for people affected by prostate cancer. These resources can help you connect with others, explore support programs, and find guidance throughout your experience.

Get connected

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Do race and ethnicity affect prostate cancer risk?

The outlook for a prostate cancer diagnosis is different among some racial and ethnic groups.

  • Survival rates for Black men are worse than than those for White men, despite having similar diagnosis rates
  • Hispanic men are underrepresented in clinical trials for prostate cancer treatments, leading to gaps in care for this group
  • Environmental stress, including neighborhood disadvantage, contributes to potentially worse outcomes for Black men
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When should I seek a second opinion?

Getting a second opinion is a common process that can give you peace of mind. You may want or need a second opinion because:

  • You have a rare type of cancer and want to be sure of your diagnosis
  • Your doctor gives you limited treatment options, and you think other treatments might be available at a different medical center
  • Your doctor is not a specialist in your type of cancer
  • Your doctor tells you there is uncertainty about your type or stage of cancer
  • You’re having trouble understanding and communicating with your doctor, or you want your options explained by someone else
  • You feel uncomfortable with your doctor and their ability to answer your questions or give you the time you need
  • Your insurance company asks you to get another opinion before you start treatment
  • You want to feel confident in your treatment plan