ATTR-CM Overview
Understanding ATTR-CM starts here.
Is it a heart condition or is it ATTR-CM?
- Treatment
How ATTR-CM is diagnosed
ATTR-CM can often be hard to diagnose. Find out about diagnosis and what you can do to help detect it early.
4 min read
Get your personalized discussion guide.
If you think you may have ATTR-CM, complete your doctor discussion guide now. Just answer a few questions about your symptoms, conditions, and medical history, to help you have a more informed conversation with your doctor or specialist.
Know the signs. Act early. Get answers.
- Treatment
Understanding the early
signs of cardiac
amyloidosis
Explore the early warning signs and symptoms of amyloidosis and find out if they could point to ATTR-CM.
4 min read
Up to 50% of people diagnosed with ATTR-CM had carpal tunnel — long before heart symptoms appeared.
Caregivers are in a unique position to help.
You know your loved ones better than anyone. Help them by creating a Doctor Discussion Guide so you can both be ready for their appointment.
My husband is my caregiver, and I couldn't do it by myself. I couldn't walk this journey without him.”
Faye, 42
Actual ATTR-CM Patient
One thing I noticed was the numbness in her legs and hands.”
Brad
Actual ATTR-CM Caregiver
ATTR-CM resources and guidance
Access information to help you recognize signs and talk with your doctor.
- Treatment
What is ATTR-CM?
Transthyretin cardiac amyloidosis (ATTR-CM) is a rare, serious and underdiagnosed heart condition. Find out what ATTR-CM is and how it affects the heart.
4 min read
- Treatment
How to talk to your doctor about ATTR-CM
Get ready for a conversation about your symptoms, diagnosis, and treatment options.
4 min read
- Lifestyle
Support groups and resources for ATTR-CM
ATTR-CM diagnosis isn’t always easy, but there are resources to help.
4 min read
Still have questions?
What is ATTR-CM?
ATTR-CM (transthyretin cardiac amyloidosis) is a rare, serious, underrecognized, and underdiagnosed type of amyloidosis that affects the heart and is associated with heart failure.
See how ATTR-CM affects your heart.
What are the 2 types of ATTR-CM?
Wild-type ATTR-CM (wATTR), which is associated with aging; and hereditary ATTR-CM (hATTR), which is caused by a gene change.
What happens to these misfolded proteins over time during ATTR-CM?
The misfolded proteins join and build up in the body, including in the heart, which causes the heart muscles to thicken and stiffen, eventually leading to heart failure.
What are some common symptoms of ATTR-CM?
In addition to heart failure, carpal tunnel, stomach issues, lumbar spine stenosis, peripheral neuropathy, and others.
Find out about the early warning signs.
Why is ATTR-CM sometimes underdiagnosed or misdiagnosed?
Awareness among patients, and even physicians, remains low, which results in ATTR-CM being significantly underdiagnosed. Underdiagnosis and delayed diagnosis occur because the symptoms of ATTR-CM mimic those of other more common causes of heart failure.
Why is it important to speak with a doctor if you have a family history of heart failure?
Because the hereditary type of ATTR-CM is passed to family members.