Understanding
ATTR-CM
starts here.

Learn about this serious heart condition, transthyretin cardiac amyloidosis, and build a personalized guide to discuss with your doctor.

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ATTR-CM is a rare heart condition that occurs when proteins called transthyretins (TTRs) misfold in the heart and other parts of your body.

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Heart failure,
carpal tunnel,
shortness
of
breath, or lower
back pain can be
warning signs.

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Think your
symptoms might
be connected?
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symptoms now.

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Find a specialist near you

On average, it can take more than 5 years to get an ATTR-CM diagnosis, and a specialist can help determine which tests you will need.


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Types of ATTR-CM
Symptoms
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Did you know
there are 2 types of
ATTR-CM?

ATTR-CM symptoms can be confusing.

Does ATTR-CM run in your family?

Family history?

This may be hereditary ATTR-CM (hATTR). Caused by inherited gene changes, it affects both men and women, as early as 50-60 years old, and disproportionately impacts African American men.

Source: Rozenbaum

No family history of ATTR-CM?

No family history?

You may have wild-type ATTR-CM (wATTR). This type is typically linked to white men 60 years or older, and is the most common form of ATTR-CM.

Source: Rozenbaum

Keep swiping to learn more about ATTR-CM

Keep learning

Swipe again to learn more about the wide range, and seemingly unrelated, ATTR-CM symptoms.

Is your heart trying to tell you something?

Cardiac symptoms

In addition to heart failure, changes in heart rhythm, lower leg swelling, being out of breath or feeling tired can point to ATTR-CM.

Sources: Curr Opin Cardiol, AM J Med

Do other things
feel off?

Non-cardiac symptoms

From carpal tunnel to eye problems to stomach issues, ATTR-CM symptoms may surprise you.

Source: Curr Opin Cardiol

Connecting the dots is the first step towards taking control.

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You're just a few short questions away from creating your personalized discussion guide to help you talk to your doctor.

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Up to 50% of people diagnosed with ATTR-CM had carpal tunnel — long before heart symptoms appeared.

Source: Rozenbaum

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Caregivers are in a unique position to help.

You know your loved ones better than anyone. Advocate for them by creating a Doctor Discussion Guide to prepare for their appointment.

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One thing I noticed was the numbness in her legs and hands.”

Brad

Actual ATTR-CM Caregiver

My husband is my caregiver, and I couldn't do it by myself. I couldn't walk this journey without him.”

Faye, 42

Actual ATTR-CM Patient

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Frequently asked questions

What is ATTR-CM?
ATTR-CM (transthyretin cardiac amyloidosis) is a rare, serious, underrecognized, and underdiagnosed type of amyloidosis that affects the heart and is associated with heart failure.
What are the 2 types of ATTR-CM?
Wild-type ATTR-CM (wATTR), which is associated with aging; and hereditary ATTR-CM (hATTR), which is caused by a gene change.
What happens to these misfolded proteins over time during ATTR-CM?
The misfolded proteins join and build up in the body, including in the heart, which causes the heart muscles to thicken and stiffen, eventually leading to heart failure.
What are some common symptoms of ATTR-CM?
In addition to heart failure, carpal tunnel, stomach issues, lumbar spine stenosis, peripheral neuropathy, and others.
Why is ATTR-CM sometimes underdiagnosed or misdiagnosed?
Awareness among patients, and even physicians, remains low, which results in ATTR-CM being significantly underdiagnosed. Underdiagnosis and delayed diagnosis occur because the symptoms of ATTR-CM mimic those of other more common causes of heart failure.
Why is it important to speak with a doctor if you have a family history of heart failure?
Because the hereditary type of ATTR-CM is passed to family members.
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