Understanding
ATTR-CM
starts here.

Learn about this serious heart condition, transthyretin cardiac amyloidosis, and build a personalized guide to discuss with your doctor.

Get started

Style
Parallax-frame, Frame-1, managebr-h1-1-desktop-hide, managebr-h1-1-2-mobile-show

ATTR-CM is a rare heart condition that occurs when proteins called transthyretins (TTRs) misfold in the heart and other parts of your body.

Get started

Style
Parallax-frame, Frame-2

Heart failure,
carpal tunnel,
shortness
of
breath, or lower
back pain can be
warning signs.

Get started

Style
Parallax-frame, Frame-3, managebr-h3-3-mobile-hide, managebr-h3-1-2-4-5-desktop-hide

Think your
symptoms might
be connected?
Check your
symptoms now.

Get started

pfizerforallcomus-main-page.web.pfizer/assets/video/media_14b823ca8c4910de3c8c1601c6e0e174be0066e61.mp4
poster
Picture
Style
Parallax-frame, Frame-4, managebr-h3-1-3-desktop-hide

Early action is key.

Style
hero-mini, Section-bg-banner, card-overlap, attr-early
id
act-early

Take a step toward answers.

This assessment will help you make the most out of conversations with your doctor.

Start now

Types of ATTR-CM
Symptoms
Style
light-blue-bg, tabs, attr-tabs

Did you know
there are 2 types of
ATTR-CM?

ATTR-CM symptoms can be confusing.

Does ATTR-CM run in your family?

Family history?

This may be hereditary ATTR-CM (hATTR). Caused by inherited gene changes, it affects both men and women, as early as 50-60 years old, and disproportionately impacts African American men.

Source: Rozenbaum

No family history of ATTR-CM?

No family history?

You may have wild-type ATTR-CM (wATTR). This type is typically linked to white men 60 years or older, and is the most common form of ATTR-CM.

Source: Rozenbaum

Keep swiping to learn more about ATTR-CM

Keep learning

Swipe again to learn more about the wide range, and seemingly unrelated, ATTR-CM symptoms.

Is your heart trying to tell you something?

Cardiac symptoms

In addition to heart failure, changes in heart rhythm, lower leg swelling, being out of breath or feeling tired can point to ATTR-CM.

Sources: Curr Opin Cardiol, AM J Med

Do other things
feel off?

Non-cardiac symptoms

From carpal tunnel to eye problems to stomach issues, ATTR-CM symptoms may surprise you.

Source: Curr Opin Cardiol

Connecting the dots is the first step towards taking control.

Connect the dots

You're just a few short questions away from creating your personalized discussion guide to help you talk to your doctor.

Get your guide

Style
cards-carousel, card-hover, footnotes-on, section-footnoteon-padding, section-bg-gray, meno-blades, covid-cards, tabbed-cards

Explore a Pfizer treatment option.

Learn more

Learn more

Style
top-padding, section-bg-white, health-wellness, attr-cm-explore
Section-name
Attr-cm pfizer treatment
Diagnosis
Testing
Style
tabs

On average, it can take more than 5 years to get an ATTR-CM diagnosis.

Too few doctors know the critical signs and symptoms of ATTR-CM, so many cases go undiagnosed. And even then, misdiagnosis can affect up to 57% of patients. That's why finding a specialist is crucial. We can help.

Source: Rozenbaum

Treatment center list provided by the Amyloidosis Foundation.

Find a specialist

Time is the most valuable thing we have. That’s why it’s incredibly important to raise awareness of ATTR-CM and get an early and accurate diagnosis. Early detection of ATTR-CM is key.

Inserting image..., Picture

Randy, 77

Real hATTR-CM Patient

Looking back, I can see that symptoms happened two years before we got the diagnosis... For me, getting diagnosed early, it changed my outlook on life"

Picture, Picture

Faye, 42

Real ATTR-CM Patient

It’s hard watching Faye go through the struggles she has but it's not gonna change how I view or her how I love her, it’s just another part of life.”

Picture, Picture

Brad

Real ATTR-CM Caregiver

style
cards-carousel, migraine-pac, mtoq-result-cards, education-tyd, quote-cards, attr-cm-cg, quote-lightblue, tab-sec

A specialist can help determine which tests you will need for a proper ATTR-CM diagnosis.

These could include routine tests like an ECG or an echocardiogram (which you may have had before) or more specialized tests, like a cardiac biopsy, cardiac MRI, or genetic testing.

Treatment center list provided by the Amyloidosis Foundation.

Find a specialist

Picture

Time is the most valuable thing we have. That’s why it’s incredibly important to raise awareness of ATTR-CM and get an early and accurate diagnosis. Early detection of ATTR-CM is key.”

Picture

Randy, 77
Real hATTR-CM Patient

style
tab-sec, specialist-sec

Up to 50% of people diagnosed with ATTR-CM had carpal tunnel — long before heart symptoms appeared.

Source: Rozenbaum

True

False

The correct answer is true!

style
Attr-cm-yesno, section-bg-white, relief-light

Caregivers are in a unique position to help.

You know your loved ones better than anyone. Advocate for them by creating a Doctor Discussion Guide to prepare for their appointment.

Get the guide

One thing I noticed was the numbness in her legs and hands.”

Brad

Actual ATTR-CM Caregiver

My husband is my caregiver, and I couldn't do it by myself. I couldn't walk this journey without him.”

Faye, 42

Actual ATTR-CM Patient

style
cards-carousel, sec-bg-pfizer-blue, migraine-pac, mtoq-result-cards, button-position, education-tyd, quote-cards, attr-cm-cg
Section-name
Caregiver-testimony
Style
needs-signup-sec, sec-bg-white

Frequently asked questions

What is ATTR-CM?
ATTR-CM (transthyretin cardiac amyloidosis) is a rare, serious, underrecognized, and underdiagnosed type of amyloidosis that affects the heart and is associated with heart failure.
What are the 2 types of ATTR-CM?
Wild-type ATTR-CM (wATTR), which is associated with aging; and hereditary ATTR-CM (hATTR), which is caused by a gene change.
What happens to these misfolded proteins over time during ATTR-CM?
The misfolded proteins join and build up in the body, including in the heart, which causes the heart muscles to thicken and stiffen, eventually leading to heart failure.
What are some common symptoms of ATTR-CM?
In addition to heart failure, carpal tunnel, stomach issues, lumbar spine stenosis, peripheral neuropathy, and others.
Why is ATTR-CM sometimes underdiagnosed or misdiagnosed?
Awareness among patients, and even physicians, remains low, which results in ATTR-CM being significantly underdiagnosed. Underdiagnosis and delayed diagnosis occur because the symptoms of ATTR-CM mimic those of other more common causes of heart failure.
Why is it important to speak with a doctor if you have a family history of heart failure?
Because the hereditary type of ATTR-CM is passed to family members.
Style
FAQ, top-padding, faq-margin
https://pfizerforallcomus-main-page.web.pfizer/global/fragment/additional-resources

Back
to top